Statistical Issues Arising in the Analysis of DNA-DNA Hybridization Data

The phylogeny of the hominoid primates: a statistical analysis of the DNA-DNA hybridization data.

Sibley and Ahlquist compared the single-copy nuclear DNA sequences of the hominoid primates using DNA-DNA hybridization. From this data set they estimated a phylogeny that clusters man and chimpanzees using a distance Wagner procedure. However, no assessment of statistical confidence in this estimated phylogeny was made, despite the fact that their data set contains internal inconsistencies con...

Statistical Methods for Analyzing DNA-DNA Hybridization Data

Further comments on the statistical analysis of DNA-DNA hybridization data.

Saitou ( 1986) and Ruvolo and Smith ( 1986) have criticized the delta Q-test that I proposed (Templeton 1985) for testing the ability of DNA-DNA hybridization data to discriminate between two alternative phylogenies. The criticisms fall into two basic categories: (1) those concerning the statistical properties of the delta Q-test and (2) those claiming that DNA-DNA hybridization data are superi...

analysis of power in the network society

اندیشمندان و صاحب نظران علوم اجتماعی بر این باورند که مرحله تازه ای در تاریخ جوامع بشری اغاز شده است. ویژگیهای این جامعه نو را می توان پدیده هایی از جمله اقتصاد اطلاعاتی جهانی ، هندسه متغیر شبکه ای، فرهنگ مجاز واقعی ، توسعه حیرت انگیز فناوری های دیجیتال، خدمات پیوسته و نیز فشردگی زمان و مکان برشمرد. از سوی دیگر قدرت به عنوان موضوع اصلی علم سیاست جایگاه مهمی در روابط انسانی دارد، قدرت و بازتولید...

Statistical issues in the analysis of DNA Copy Number Variations

Approaches to assess copy number variation have advanced rapidly and are being incorporated into genetic studies. While the technology exists for CNV genotyping, a further understanding and discussion of how to use the CNV data for association analyses is warranted. We present the options available for processing and analysing CNV data. We break these steps down into choice of genotyping platfo...